ODCs

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2 OMIM references -
1 associated gene
10 signs/symptoms

PROTEIN INTERACTIONS: 2
COMMON SIGNS: 1

2 OMIM references -
2 associated genes
10 signs/symptoms

Fibronectin glomerulopathy

Epidermolytic ichthyosis

FN1	(UniProt - OMIM)		KRT1	(UniProt - OMIM)
			KRT10	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	FN1 FN1	(0.72) (0.72)	KRT1 KRT10

Citations in the biomedical literature:

Fibronectin glomerulopathy		Epidermolytic ichthyosis
	Synonym(s): - GFND - Glomerulopathy with fibronectin deposits		Synonym(s): - BCIE - Bullous congenital ichthyosiform erythroderma - Bullous congenital ichthyosiform erythroderma of Brock - Bullous ichthyosis - EHK - EI - Epidermolytic hyperkeratosis

	Classification (Orphanet): - Rare genetic disease - Rare renal disease		Classification (Orphanet): - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Diseases of the genitourinary system -		Classification (ICD10): - Congenital malformations, deformations and chromosomal abnormalities -

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: variable Average age of death: - Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: 1-9 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal dominant

	External references: 2 OMIM references - No MeSH references		External references: 2 OMIM references - No MeSH references


COMMON SIGNS	- Autosomal dominant inheritance

Fibronectin glomerulopathy		Epidermolytic ichthyosis
	Very frequent - Chronic arterial hypertension - Edema of the legs / lower limbs - Functional anomalies of the kidney and the urinary tract - Hematuria / microhematuria - Nephrotic syndrome - Proteinuria - Renal failure - Renal glomerular defect / glomerulopathy Occasional - Intracranial / cerebral / meningeal hemorrhage		Very frequent - Erythema / erythematous lesions / erythroderma / polymorphous erythema - Hyperkeratosis / ainhum / hyperkeratotic skin fissures - Ichthyosis / ichthyosiform dermatitis - Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Pigmented naevi / naevus pigmentosus / lentigo Occasional - Chronic skin infection / ulcerations / ulcers / cancrum - Follicular / conjunctival hamartomas - Palmoplantar hyperkeratosis / keratoderma